Remdesivir Injection Uses, Side effects, Interactions & Prepration for Intravenous solution

Remdesivir ek broad-spectrum antiviral medication hain generally ise intravenously diya jata hain

Remdesivir ko Gilead Sciences ne 2009 main Hepatitis C naami bimari ko rokne ke liye banaya gaya tha phir bad main ise Ebola virus aur Marburg virus se hone wali bimariyo main use kiya jane laga

November 2020 main WHO ne kuch trails ke bad remdesivir ko approve kiya COVID‑19 ke treatment ke liye ( for emergency use only ) in around 50 countries

FDA ne is dawai ko filhal general use ke liye approve nahi kiya hain kyuki is waqt hamare pas is dawai ke safety aur effectiveness se related compelte information available nahi hain.

Remdesivir for Emergency Use Only

3 clinical trials jo ke 2043 hospitalized participants par hue

ye trails 226 sites aur 17 countries main hue.

par dekha gaya ke covid patients main is dawai ka positive respose raha hain

ayse patients jin ka treatment Remdesivir se hua unki recovery jladi hui unke muqable main jo patients kisi aur medicines se apna treatment karwa rahe the

ramdesvir sirf ayse patients ko diya ja raha hain jo hospitalized ho, jinhain severve covid infection ho aur ayse patients jin ka oxygen saturation (SpO2) 94 % se kam ho

remdesvir RNA dependent enzyme/RNA polymerase ko rokta hai jo ke SARS-CoV-2 virus ki help karta hain viruses ki copies banane main is tarh ramdesvir body ke viral load ko kam karta hain

Remdesvir se hone wale side effects main sab se common hain respiratory failure, anemia

anemia yani low number of red blood cells

RBC ke ilawa Albumin, Potassium aur Thrombocytes bhi kam ho sakte hain

Nausea, Vomiting, Fever aur Kidney damage wagira jaise side effects bhi dekhne ko milte hain

Remdesvir ko intravenously diya jata hain jis ki wajh se kuch Infusion‐related reactions ho sakte hain

serious allergic reaction main aapko kuch symptoms jaise ke skin rash, itching/swelling (especially of the face/tongue/throat), trouble breathing , severe dizziness ho sakte hain

blood pressure levels ka kam hojana aur liver enzymes ka badh jana ye bhi remdesvir se hone wale side effects hain

DOSE OF REMDESIVER

COVID-19 infection ke treamtment ke liye Remdesvir ko hospitalized adults aur children ko diya jata hain jinki age 12 sal ya us se zayada honi cahiye aur weight at least 88 pounds ya 40 kilogram hona chahiye

Remdesvir ko daily 30 minutes se 120 minutes tak 5 se 10 dino ke liye intravenous infusion se diya jata hain

First day Remdesvir ka loading dose 200mg hota hain and

second day Remdesvir ka ka maintenance dose 100mg hota hain

dose aur duration of treatment seriousness of disease or infection par depend karta hain.

DRUG INTERACTION OF REMDESIVER

Drug Interactions :

Remdesivir ko chloroquine or hydroxychloroquine ke sath dene par Remdesivir ki Antiviral activity kam ho jati hain jise hum Drug-Drug Interaction kehte hain

Remdesivir partially cytochrome P450 ke zariye metabolize hota hain

(enzymes CYP2C8, CYP2D6, and CYP3A4)

agar use cytochrome P450 inducers ke sath diya jaye to Remdesivir ka Blood plasma concentrations kam ho sakta hain cytochrome P450 inducers jaise

phenytoin,phenobarbital, rifampicin,carbamazepine, primidone, and St John's wort

CYTOCHROME P450 INDUCER

KIDNEY AND LIVER DISEASE DRUG -DISEASE INTRACTION

Remdesivir ka ek vial 100mg ka hota jo ke ek lyophilized powder hain jismain 3g SBECD hota hain SBECD yani (sulfo-butyl-ether beta-cyclo-dextrin sodium ) ye ek vehicle hain jo kidney ke zariye eliminate hota hain

agar kisi patient ko Remdesivir ka loading dose diya jaya jo ke 200mg hota hain to us patient ko 6 g SBECD bhi jayega (SBECD 6 -12 grams bhi ho sakta hain depending upon formulation )

Itna amount safe hota hain par jin logo ko renal ya kidney disease ho unke liye Remdesivir Unsafe hota hain kyunke ye kidney main jama hoskta hain jis se liver aur renal toxicities ho sakti hain

Ise sirf sterile water se hi banaya jata jain jo ke injections ke liye use hota hain

q ke is mai microoraganism nhi hote yani ise aseptically bana hota hain

suitbale syring aur needle ki madad se Remdesivir 100mg lyophilized powder main 19 ml Sterile Water for Injection add karna hota hain

(aysa vacuum jis se vial main mojud SWFI kheecha na ja sake ayse vials ko discard kar dena behtar hain )

jaise hi aap ne add kiya 30 seconds tak shake karna hota hain

vial main jo contents hote hain unhain settle hone main 2 se 3 minuts lagte hain uske bad ek clear solution milega

(agar vial ke contents commpletley dissolve nahi hue ho to 2 se 3 minutes tak dobara shake karain aur tab tak shake karain jab tak content dissolve na hojaye if tab bhi na ho to vial ko discard kar dain )

vial main jo content hoga wo 100mg/20ml yani 5mg/ml of Remdesivir solution hoga

dilution procees karte waqt aapko microbial contamination se mixture bachna hota hain kyunki is main kisi bhi tarh ke preservative or bacteriostatic agent nahi hote iske liye aseptic technique use karni hoti hain

jaise hi parentral prepration tayyar hojaye use immediatly use kar lena behatr hota hain

100mg/20ml remdesivir solution ko 100ml / 250ml 0.9% sodium chloride main dilute kiya jata hain jo ke infusion bag main hota hain

Dilution Instructions of Reconstituted Remdesivir for Injection Lyophilized Powder

DILUTION PROCESS OF REMDESIVIR

jo remdesivir banaya gaya hain use infusion bag main dalna hota hain

ise mix karne ke liye 15 se 20 bar invert karte hain kabhi bhi shake nahi karte

jo infusion banaya jata hai wo sirf 24 ghanto tak room temperature (20°C to 25°C [68°F to 77°F])par stable hota hain aur refrigerated temperature (2°C to 8°C [36°F to 46°F])par 48 hours ghnato tak

Recommended Rate of Infusionâ€”Diluted VEKLURY for Injection Lyophilized Powder in Adults and Pediatric Patients 12 Years of Age and Older and Weighing at Least 40 kg